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Single‑cell RNA sequencing unveils fibroblast heterogeneity in proliferative vitreoretinopathy membranes

GSE294329 Homo sapiens Expression profiling by high throughput sequencing 5 samples Submitted 2025/12/13 Platform GPL24676
Summary
Proliferative vitreoretinopathy (PVR) is a vision-threatening fibrotic disorder characterized by pathological membrane formation, yet its cellular and molecular mechanisms remain incompletely understood. Here, we employed single-cell RNA sequencing (scRNA-seq) to profile 18,213 cells from 5 human PVR membranes (PVRMs), uncovering cellular heterogeneity and novel pathogenic pathways.
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Direct links to NCBI, no account and no request form: the whole study as GSE294329_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1249038 and SRA study SRP578144. Searching any of these in the dataset finder brings you back here.

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