Multiomic single nuclei profiling of a mouse model of Alzheimer’s disease reveals that ACSS2 confers neuronal resilience to tauopathy
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 49 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 49 samples: 18 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multiomic single nuclei profiling the mouse hippocampus reveals that ACSS2 confers neuronal resilience to tauopathyAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE294332_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1249036 and SRA study SRP577682. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 49 samples.
How we read this: 18 replicated groups read from 49 sample titles; they account for 49 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8901194 male-KO-PBS.751 male-KO-PBS
- GSM8901195 male-KO-PBS.752 male-KO-PBS
- GSM8901196 male-KO-PBS.753 male-KO-PBS
- GSM8901197 male-WT-PBS.791 male-WT-PBS
- GSM8901198 male-WT-PBS.792 male-WT-PBS
- GSM8901199 male-WT-PBS.793 male-WT-PBS
- GSM8901200 female-KO-Tau.314 female-KO-Tau
- GSM8901201 female-KO-Tau.324 female-KO-Tau
- GSM8901202 female-KO-Tau.325 female-KO-Tau
- GSM8901203 male-KO-Tau.711 male-KO-Tau
- GSM8901204 male-KO-Tau.712 male-KO-Tau
- GSM8901205 male-KO-Tau.713 male-KO-Tau
- GSM8901206 female-WT-Tau.331 female-WT-Tau
- GSM8901207 female-WT-Tau.341 female-WT-Tau
- GSM8901208 male-WT-Tau.771 male-WT-Tau
- GSM8901209 male-WT-Tau.772 male-WT-Tau
- GSM8901210 male-WT-Tau.773 male-WT-Tau
- GSM8902490 PBS injected control diet 1 PBS injected control di…
- GSM8902491 PBS injected control diet 2 PBS injected control di…
- GSM8902492 PBS injected control diet 3 PBS injected control di…
- GSM8902493 PBS injected acetate diet 1 PBS injected acetate di…
- GSM8902494 PBS injected acetate diet 2 PBS injected acetate di…
- GSM8902495 PBS injected acetate diet 3 PBS injected acetate di…
- GSM8902496 Tau injected control diet 1 Tau injected control di…
- GSM8902497 Tau injected control diet 2 Tau injected control di…
- GSM8902498 Tau injected control diet 3 Tau injected control di…
- GSM8902499 Tau injected acetate diet 1 Tau injected acetate di…
- GSM8902500 Tau injected acetate diet 2 Tau injected acetate di…
- GSM8902501 Tau injected acetate diet 3 Tau injected acetate di…
- GSM8918999 Input.Tau-KO.321 Input.Tau-KO
- GSM8919000 Input.Tau-KO.322 Input.Tau-KO
- GSM8919001 Input.Tau-KO.323 Input.Tau-KO
- GSM8919002 Input.Tau-WT.333 Input.Tau-WT
- GSM8919003 Input.Tau-WT.334 Input.Tau-WT
- GSM8919004 Input.Tau-WT.335 Input.Tau-WT
- GSM8919005 Input.PBS-KO.353 Input.PBS-KO
- GSM8919006 Input.PBS-KO.354 Input.PBS-KO
- GSM8919007 Input.PBS-WT.362 Input.PBS-WT
- GSM8919008 Input.PBS-WT.363 Input.PBS-WT
- GSM8919009 H3K27ac.Tau-KO.321 H3K27ac.Tau-KO
+ 9 more — browse all 49 samples with per-sample file links →
- GSE294751 Multiomic single nuclei profiling of a mouse model of Alzheimer’s disease reveals that ACSS2 confers neuronal resilience to tauopathy [ChIP-seq] 20 samples shares acss2, resilience, multiomic, alzheimer, tauopathy, neuronal, confers
- GSE76853 Acetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [RNA-seq] 16 samples shares acss2, neuronal
- GSE254104 Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model [snRNAseq] 27 samples shares alzheimer, tauopathy
- GSE254103 Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model [bulk_RNAseq] 24 samples shares alzheimer, tauopathy
- GSE291086 Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer’s disease 24 samples shares alzheimer, neuronal
- GSE292137 Excitatory Neuronal ErbB4 Drives Early Pathophysiology of Alzheimer's Disease 18 samples shares alzheimer, neuronal
- GSE328769 Alzheimer's disease associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor Gbf1 16 samples shares alzheimer, neuronal
- GSE279550 Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease Pathogenesis 16 samples shares alzheimer, neuronal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.