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Differential contribution of TFE3 isoforms to cell motility and invasion

GSE294493 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/03 Platform GPL18573
Summary
We and other have previously reported that TFE3 migrates as two distinct bands of approximately 72 and 82 kDa in SDS-PAGE. Interestingly, whereas the smaller form of TFE3 is always present in cell lysates, the higher molecular weight form appears only after specific stress conditions, such as prolonged starvation. A recent report suggested that the 82 kDa form does in fact corresponds to TFE3 full length (TFE3-L). It was proposed that the control of TFE3 stability may constitute the main mechanism of TFE3 regulation. There is, however, a critical question that remains to be addressed regarding the role of the 72 kDa TFE3 short isoform (TFE3-S). TFE3-S is expressed at high levels in most cell types and its expression remains constant both under control and stress conditions. Characterizing the nature and regulation of TFE3-S, as well as its potential transcriptional activity and selectivity, is therefore essential to fully understand TFE3 regulation.
Published in
Differential contribution of TFE3 isoforms to cell motility and invasion
Contreras PS, Martina JA, Rollins K et al. · EMBO reports 2026 · PMID 41361692 · doi:10.1038/s44319-025-00659-3
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Also filed as BioProject PRJNA1250394 and SRA study SRP578401. Searching any of these in the dataset finder brings you back here.

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