← BioTransfer GEO Dataset Finder
GEO series

Low expression of ALOX15B modulates immunosuppressive tumor microenvironment in diffuse large-B cell lymphoma via the TAP1/MHC-I axis

GSE294509 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/02/18 Platform GPL34290
Summary
The arachidonic acid (AA) metabolism is closely related to tumor immune evasion and chemo-resistance. ALOX15B (arachidonate 15-lipoxygenase type B), located on chromosome 17p, encodes a key enzyme in AA pathway. Interestingly, the expression of ALOX15B is independent of 17p status but is epigenetically regulated. Low ALOX15B expression predicts poor prognosis, with PGE2 activation and TAP1 suppression, reducing MHC-I expression and creating an immunosuppressive microenvironment. Tucidinostat, a histone deacetylase (HDAC) inhibitor, restores ALOX15B and enhances the TAP1/MHC-I axis, thus promoting lymphoma cell apoptosis, which correlates with the effect of tucidinostat plus immunochemotherapy in a phase II trial of patients with newly diagnosed DLBCL (NCT02753647). Our study provides insight into a novel therapeutic strategy to improve patient prognosis by epigenetically modulating lymphoma metabolism and optimizing the tumor microenvironment.
Published in
Low expression of ALOX15B modulates immunosuppressive tumor microenvironment in diffuse large B-cell lymphoma via the TAP1/MHC-I axis
Wang L, Liu J, Shang Y et al. · Journal of experimental & clinical cancer research : CR 2026 · PMID 41527135 · doi:10.1186/s13046-025-03613-2
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE294509_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1250420 and SRA study SRP578608. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.