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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [PS_CUTnRUN]

GSE294520 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/07/21 Platform GPL34290
Summary
We discovered a role for the transcription factor OTX2 in formation of mouse definitive endoderm (DE). We used CUT&RUN to map OTX2-bound genomic regions and identify OTX2-regulated genes during directed differentiation of EpiSCs to DE
Published in
Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm
Ee LS, Medina-Cano D, Goetzler E et al. · Developmental cell 2025 · PMID 40834858 · doi:10.1016/j.devcel.2025.07.020
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Also filed as BioProject PRJNA1250433 and SRA study SRP578398. Searching any of these in the dataset finder brings you back here.

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