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Spatial transcriptomics reveal lineage complexity of gastric incomplete intestinal metaplasia and its association with gastric cancers [ATAC-Seq]

GSE294729 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 5 samples Submitted 2025/12/30 Platform GPL33758
Summary
This research underscores the unique molecular phenotype and lineage complexity of Inc IM, emphasizing its significance as a precancerous lesion in gastric tissues. Our findings lay the groundwork for future investigations into the epigenetic and transcriptional dynamics governing metaplastic changes, highlighting the importance of Inc IM in GC progression.
Published in
Hybrid identity and distinct methylation profiles of incomplete intestinal metaplasia in the stomach
Kim H, Kim J, Jeong IH et al. · Gut 2025 · PMID 40691053 · doi:10.1136/gutjnl-2025-335793
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Also filed as BioProject PRJNA1251512 and SRA study SRP578979. Searching any of these in the dataset finder brings you back here.

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