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A lineage shared core gene expression network specific to human infants, links human evolution to ASD in oligodendrocytes and Parkinsons disease in neurons

GSE294786 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/24 Platform GPL16791
Summary
Human-specific faculties of neural development at the postnatal stage are largely unknown, as evolutionary comparisons have either relied on adult material, immature cell culture proxies, or comparisons with more distant species. To address this, we performed snRNAseq (10x Genomics) on rare human, chimpanzee, and rhesus macaque prefrontal cortex (PFC) infant samples. This study represents the first to include infant chimpanzee samples in such evolutionary comparisons, providing novel insight into human-specific neural development and its susceptibility to neural disease.
Published in
Charting the human-specific properties of gene expression networks in the infant prefrontal cortex
Klavert J, Radjabzadeh D, Gonzalez Sanchez E et al. · Science advances 2026 · PMID 42234754 · doi:10.1126/sciadv.aea3316
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Also filed as BioProject PRJNA1251600 and SRA study SRP579160. Searching any of these in the dataset finder brings you back here.

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