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Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_nuclei]

GSE294860 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/02 Platform GPL30215
Summary
Using high-resolution single-cell RNA sequencing, we systematically characterized hepatocyte adaptations in mice across pregnancy and postpartum stages. We discovered a cyclical hepatocyte trajectory (“pregnancy clock”) governing metabolic changes during gestation and postpartum recovery, which reverted to pregestational states in non-lactating mice. Lactation induced a distinct branching trajectory characterized by elevated lipid synthesis and export. Deletion of gp130 disrupted hepatic adaptations during pregnancy, impairing fetal growth, whereas ACSS2 deficiency postpartum disrupted lipid export, affecting milk quality and offspring growth.
Published in
Hepatocyte metabolic adaptations during pregnancy and lactation
Yang L, Zhang Y, Yu XX et al. · Cell 2025 · PMID 40882627 · doi:10.1016/j.cell.2025.08.007
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Also filed as BioProject PRJNA1251713 and SRA study SRP579173. Searching any of these in the dataset finder brings you back here.

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