← BioTransfer GEO Dataset Finder
GEO series

Epigenetic characterization of T progenitor exhausted and terminally exhausted T cells in chronic infection [ATACseq_Prdm1YFP]

GSE294878 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2025/10/02 Platform GPL17021
Summary
Exhausted T cells are a heterogeneous population of antigen-reactive CD8+ T cells elicited by chronic antigen exposure. T progenitor exhausted (TPEX) and terminally exhausted (TEX) cells exhibit distinct gene expression profiles, but how their chromatin accessibility profiles differ remains incompletely defined. This dataset interrogates genome-wide differences in chromatin accessibility of Prdm1YFP+TIM3+ (TEX), Prdm1YFP-TIM3-(TPEX), and Prdm1YFP+TIM3- cells.
Published in
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8(+) T cells
Murphy MK, McCullen M, Deffenbaugh JL et al. · Immunity 2025 · PMID 41043414 · doi:10.1016/j.immuni.2025.09.008
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE294878_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1251117 and SRA study SRP578846. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.