The Role of PD-1/PD-L1 in Overshooting Osteoclastogenesis in Periprosthetic Joint Infections
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The role of PD-1/PD-L1 in overshooting osteoclastogenesis in periprosthetic joint infectionsCommunications biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE295042_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1252699 and SRA study SRP579695. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8941057 CD14+ PBMCs, blank control 1, stimulation - MCSF, Day 18
- GSM8941058 CD14+ PBMCs, blank control 2, stimulation - MCSF, Day 18
- GSM8941059 CD14+ PBMCs, blank control 3, stimulation - MCSF, Day 18
- GSM8941060 CD14+ PBMCs, control 1, stimulation - MCSF + RANKL, Day 18
- GSM8941061 CD14+ PBMCs, control 2, stimulation - MCSF + RANKL, Day 18
- GSM8941062 CD14+ PBMCs, control 3, stimulation - MCSF + RANKL, Day 18
- GSM8941063 CD14+ PBMCs, stimulating PD-1 1, stimulation - MCSF + RANKL + sPD-L1, Day 18
- GSM8941064 CD14+ PBMCs, stimulating PD-1 2, stimulation - MCSF + RANKL + sPD-L1, Day 18
- GSM8941065 CD14+ PBMCs, stimulating PD-1 3, stimulation - MCSF + RANKL + sPD-L1, Day 18
- GSM8941066 CD14+ PBMCs, inhibiting PD-1 1, stimulation - MCSF + RANKL + Nivolumab, Day 18
- GSM8941067 CD14+ PBMCs, inhibiting PD-1 2, stimulation - MCSF + RANKL + Nivolumab, Day 18
- GSM8941068 CD14+ PBMCs, inhibiting PD-1 3, stimulation - MCSF + RANKL + Nivolumab, Day 18
- GSE238145 Batf3-dendritic cells and 4-1BB/4-1BB ligand axis are required at the effector phase within the tumor microenvironment for PD-1/PD-L1 blockade efficacy 10 samples shares pd-l1, pd-1
- GSE285029 Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/Jak/Stat3 in PD-L1-high lung cance 234 samples shares pd-l1
- GSE319722 Spatial dynamics links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in microsatellite stable colorectal cancer 117 samples shares pd-l1
- GSE176021 Distinct transcriptional programs characterize neoantigen-specific T cells in lung cancers treated with neoadjuvant PD-1 blockade [single-cell RNA-seq] 110 samples shares pd-1
- GSE212217 Distinct Mechanisms of Mismatch-Repair Deficiency Delineate Two Modes of Response to Anti–PD-1 Immunotherapy in Endometrial Carcinoma 104 samples shares pd-1
- GSE268243 Role of Forkhead Box P3 in Interferon g-mediated PD-L1 Expression and Bladder Cancer Differentiation 12 samples shares pd-l1
- GSE265899 Spatially resolved whole-transcriptomic and proteomic profiling of lung cancer and immune-microenvironment according to PD-L1 expression 95 samples shares pd-l1
- GSE308973 Localized PD-1 CAR T therapy reprograms neuroinflammation - human CSF data. 88 samples shares pd-1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.