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Single-cell epigenetic landscape, microenvironment interactions, and gene regulatory modules of non-functioning pituitary adenomas (NFPA)

GSE295046 Homo sapiens Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2026/03/16 Platform GPL24676
Summary
The epigenetic landscape and tumor microenvironment (TME) interactions of non-functioning pituitary adenomas (NFPAs), benign tumors with high morbidity and recurrence rates, are not well characterized. We completed single-nucleus (sn) multiomics assays on four gonadotrope NFPAs. We identified genes involved in bidirectional tumor-macrophage crosstalk. We uncovered coordinated gene expression and chromatin accessibility programs that distinguished adenoma cells from gonadotropes. Integrated transcriptome-chromatin modeling revealed gene regulatory circuits that showed altered activity in adenoma cells. Our study provides insight into the altered epigenetic gene-control landscape and TME processes of the NFPA tumor phenotype.
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Also filed as BioProject PRJNA1252709 and SRA study SRP579721. Searching any of these in the dataset finder brings you back here.

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