GEO series
A Natural Cyclic Peptide Enhances Cytotoxic Th9 Differentiation and Antitumor Immunity
GSE295054
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/11/28
GPL34290
Summary
Adoptive cell therapy (ACT) relies on durable and functional T cells to mediate tumor clearance. Th9 cells are a metabolically fit CD4⁺ T cell subset with strong persistence but limited cytotoxicity. Here, we identify Endomelipaneptide A (EpA), a cyclic peptide from Ganoderma lucidum–associated endophytic fungi, as a potent enhancer of Th9 differentiation. EpA promotes a cytotoxic Th9 phenotype with enhanced mitochondrial function and metabolic fitness.
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Paper (PMID 41364522) ↗
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