Effect of MetAP2 Inhibitor Evexomostat (SDX-7320) on Gene Expression in MC38 Tumors from Lean and Obese Mice
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Evexomostat (SDX-7320), a methionine aminopeptidase type 2 inhibitor, stimulates weight loss and inhibits obesity-accelerated tumor growthFrontiers in oncology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE295063_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1252740 and SRA study SRP579714. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 16 more — browse all 16 samples with per-sample file links →
- GSE288240 Histone deacetylase enzyme activity is not the universal anti-cancer target of HDAC inhibitors [RNA-seq_MC38] 9 samples shares mc38, inhibitor
- GSE316313 Single-cell RNA sequencing of MC38 subcutaneous allograft tumors in C57BL/6J mice treated with FOLFOX alone or in combination with a composite probiotics 9 samples shares mc38
- GSE236227 Transcriptional analysis of CD8+ T lymphocytes isolated from syngeneic MC38 tumors implanted in young adult or aged mice 8 samples shares mc38
- GSE251810 RNA-Seq of GB2-treated and untreated MC38 tumors 6 samples shares mc38
- GSE280847 scRNA-seq analysis of Cd45+ cells isolated from MC38 tumors inoculated in p53+/-, Lck-Cre and p53fl7KQ/-, Lck-Cre mice 4 samples shares mc38
- GSE244139 Intracellular zinc protects tumors from T cell-mediated cytotoxicity [MC38 RNAseq] 4 samples shares mc38
- GSE307699 scRNA-seq of MC38 syngeneic colorectal tumors after FAP-CAR mRNA-LNP therapy 3 samples shares mc38
- GSE294033 scRNAseq of MC38 mouse tumors reveals diverse functions of LMO7 in regulating tumor microenvironment 2 samples shares mc38
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.