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Epigenetically regulated expression of ALDH1 by anthracyclines causes an adaptive oxidative response and drug resistance in AML

GSE295068 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/12/03 Platform GPL18573
Summary
To investigate drug-induced epigenetic resistance in AML, the K562 cell line was selected due to its responsiveness to anthracyclines and its ease of genetic manipulation. Daunorubicin (DNR) was chosen as a model drug because of its pivotal role in AML treatment. DNR treatment of K562 cells induced expression of all three ALDH1 isoforms. To explore the activation of cis-regulatory elements, ChIP-Seq with H3K27Ac was performed on K562 cells treated or not with DNR for 18 hours.
Published in
Upregulation of ALDH1 as an adaptive epigenetic response to anthracyclines in acute myeloid leukemia
Leonetti F, Kosanovic S, Rebollidos-Rios R et al. · HemaSphere 2025 · PMID 41164352 · doi:10.1002/hem3.70244
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Also filed as BioProject PRJNA1252749 and SRA study SRP579739. Searching any of these in the dataset finder brings you back here.

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