ATACseq on giredestrant-resistant ER+ breast cancer cell lines
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 18 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER(+) HER2(-) locally-advanced or metastatic breast cancerNature communications · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE295128_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1253599 and SRA study SRP580173. Searching any of these in the dataset finder brings you back here.
The grouping that defines any comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Sample titles run SAM24456517 … SAM24456534 and carry no group information.
- GSM8942591 SAM24456517
- GSM8942592 SAM24456518
- GSM8942593 SAM24456519
- GSM8942594 SAM24456520
- GSM8942595 SAM24456521
- GSM8942596 SAM24456522
- GSM8942597 SAM24456523
- GSM8942598 SAM24456524
- GSM8942599 SAM24456525
- GSM8942600 SAM24456526
- GSM8942601 SAM24456527
- GSM8942602 SAM24456528
- GSM8942603 SAM24456529
- GSM8942604 SAM24456530
- GSM8942605 SAM24456531
- GSM8942606 SAM24456532
- GSM8942607 SAM24456533
- GSM8942608 SAM24456534
- GSE142751 Genome-wide maps of chromatin state in 142 cancer cell lines [cell line] 855 samples shares lines
- GSE271175 Genome-wide maps of chromatin state in 142 cancer cell lines [patient] 22 samples shares lines
- GSE289805 Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response [ChIP-seq/ATAC-seq] 126 samples shares breast
- GSE316389 Chromatin accessibility and gene expression profiling of primary and metastatic ER+ breast cancer [ATAC-seq] 36 samples shares breast
- GSE259248 ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancer (ChIP-Seq) 36 samples shares breast
- GSE291224 AF9/KLF2 gene regulatory circuit links histone lactylation to breast cancer metastasis [CUT&Tag] 22 samples shares breast
- GSE283522 The spatially informed mFISHseq assay resolves biomarker discordance and predicts treatment response in breast cancer 1254 samples shares breast
- GSE169246 PD-L1 blockade-induced temporal single cell dynamics in triple negative breast cancer 83 samples shares breast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.