Selective GSK3α Inhibition Promotes Self-Renewal Across Different Stem Cell States
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 19 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 15 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Selective GSK3α Inhibition Promotes Self-Renewal Across Different Stem Cell StatesbioRxiv : the preprint server for biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE295266_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1253965 and SRA study SRP580396. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 19 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8944529 ESC-BRD0705/PD03-rep1
- GSM8944530 ESC-BRD0705/PD03-rep2
- GSM8944531 ESC-BRD0705/PD03-rep3
- GSM8944532 ESC2i-rep1
- GSM8944533 ESC2i-rep2
- GSM8944534 ESC2i-rep3
- GSM8944535 scRNA-seq_co-culture
- GSM8944536 H3K27ac_naive ESCs
- GSM8944537 H3K27ac_primed EpiSCs
- GSM8944538 H3K27ac_co-culture_EpiSCs
- GSM8944539 H3K27ac_co-culture_ESCs
- GSM8944540 H3K27me3_naive ESCs
- GSM8944541 H3K27me3_primed EpiSCs
- GSM8944542 H3K27me3_co-culture_EpiSCs
- GSM8944543 H3K27me3_co-culture_ESCs
- GSM8944544 H3K4me3_naive ESCs
- GSM8944545 H3K4me3_primed EpiSCs
- GSM8944546 H3K4me3_co-culture_EpiSCs
- GSM8944547 H3K4me3_co-culture_ESCs
- GSE335147 Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response 24 samples shares inhibition, across, states
- GSE245287 Beta-catenin deletion and GSK3b inhibition in B-ALL cells 12 samples shares gsk3, inhibition
- GSE179151 Influence of GSK3 inhibition and beta Catenin stabilisation on the transcriptome of pre B cells 12 samples shares gsk3, inhibition
- GSE215181 Selective requirement of 3D genomic organization for the Mdm1-Il22-Ifng locus regulation in initial Th1 cell lineage specification and differentiation 135 samples shares selective, different
- GSE204933 Age-associated chromatin reorganization drives overexpression of a novel Btaf1 variant regulating HSC self-renewal and MkP differentiation in male mice 82 samples shares self-renewal, different
- GSE215177 Selective requirement of 3D genomic organization for the Mdm1-Il22-Ifng locus regulation in initial Th1 cell lineage specification and differentiation 69 samples shares selective, different
- GSE281823 Transcriptional profiling of striatum from the Q140 mouse model of Huntington's disease, from A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy 40 samples shares selective, across
- GSE230771 Differential Effects of JAK1 vs. JAK2 Inhibition in Mouse Models of Hemophagocytic Lymphohistiocytosis 30 samples shares inhibition, different
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.