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Nicotinamide Mononucleotide alleviates aging defects of Hutchinson-Gilford progeria syndrome

GSE295355 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/08/01 Platform GPL24676
Summary
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder characterized by mutations in the LMNA gene, resulting in progerin accumulation and accelerated aging, with limited therapeutic options currently available. This study demonstrates the significant therapeutic potential of nicotinamide mononucleotide (NMN) in alleviating HGPS phenotypes at both cellular and organismal levels. Using patient-derived induced pluripotent stem cell-mesenchymal stem cells (iPSC-MSCs), we demonstrated that enhancing NAD+ biosynthesis through NMN supplementation effectively restored mitochondrial function, reduced DNA damage and inflammatory markers, and mitigated oxidative stress. Furthermore, in G608G transgenic mouse models receiving NMN administration over four months, we observed significant improvements in fertility and gonadal function, enhanced cardiovascular parameters, ameliorated skin pathology, and extended lifespan. These comprehensive findings establish NMN supplementation as a promising therapeutic strategy for HGPS and potentially other aging-related disorders.
Published in
Nicotinamide Mononucleotide Alleviates Aging Defects in Hutchinson-Gilford Progeria Syndrome
Xu Y, Wu M, Fan Y et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 · PMID 40742332 · doi:10.1096/fj.202500469RR
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Also filed as BioProject PRJNA1254259 and SRA study SRP580611. Searching any of these in the dataset finder brings you back here.

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