GEO series
Targeting branched-chain amino acids alleviates pulmonary fibrosis [ATAC-seq]
GSE295423
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2026/03/17
GPL34290
Summary
Purpose: Previous studies demonstrated that BCAA metabolic reprogramming induces idiopathic pulmonary fibrosis (IPF). This study investigates BCAA-mediated gene expression regulation in primary mouse lung fibroblasts (MLFs). Methods: MLFs were cultured in three media conditions: complete medium (Complete), BCAA-free medium (Free), or BCAA-free medium supplemented with BCAAs (Free+BCAA) for 24 hours prior to TGF-β1 (20 ng/mL) stimulation for 48 hours. ATAC-seq analyses were conducted on treated MLFs. Conclusions: BCAA plays a crucial role in modulating the chromatin state of key fibrotic genes.
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Paper (PMID 42045225) ↗
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