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Single cell landscape of MBL/CLL transition [MBL_CLL_GEO_DataSet1]

GSE295489 Homo sapiens Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2026/03/31 Platform GPL24676
Summary
The transition of monoclonal B cell lymphocytosis (MBL) to chronic lymphocytic leukemia (CLL) remains ill-defined at the epigenetic and transcriptional level. Here, we performed single cell RNA and ATAC sequencing of low-count (LC) and high-count (HC) MBL and CLL blood samples to track the continuum from physiologic B cells to CLL.
Published in
Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia
Rathgeber AC, Fernandes SM, Nagler A et al. · Genome biology 2026 · PMID 41987205 · doi:10.1186/s13059-026-04072-4
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Direct links to NCBI, no account and no request form: the whole study as GSE295489_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1254969 and SRA study SRP580958. Searching any of these in the dataset finder brings you back here.

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