CNS infiltration by Tet2-mutant peripheral myeloid cells protects from Alzheimer’s Disease
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TET2-mutant myeloid cells mitigate Alzheimer's disease progression via CNS infiltration and enhanced phagocytosis in miceCell stem cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE295935_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1256817 and SRA study SRP582133. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8961709 WT_Control_rep1 WT_Control
- GSM8961710 WT_Control_rep2 WT_Control
- GSM8961711 WT_Control_rep3 WT_Control
- GSM8961712 DNMT3A_Control_rep1 DNMT3A_Control
- GSM8961713 DNMT3A_Control_rep2 DNMT3A_Control
- GSM8961714 DNMT3A_Control_rep3 DNMT3A_Control
- GSM8961715 TET2_Control_rep1 TET2_Control
- GSM8961716 TET2_Control_rep2 TET2_Control
- GSM8961717 TET2_Control_rep3 TET2_Control
- GSM8961718 WT_LPS_rep1 WT_LPS
- GSM8961719 WT_LPS_rep2 WT_LPS
- GSM8961720 WT_LPS_rep3 WT_LPS
- GSM8961721 DNMT3A_LPS_rep1 DNMT3A_LPS
- GSM8961722 DNMT3A_LPS_rep2 DNMT3A_LPS
- GSM8961723 DNMT3A_LPS_rep3 DNMT3A_LPS
- GSM8961724 TET2_LPS_rep1 TET2_LPS
- GSM8961725 TET2_LPS_rep2 TET2_LPS
- GSM8961726 TET2_LPS_rep3 TET2_LPS
- GSE280720 Functional characterization of Central Nervous System (CNS) and peripheral immune responses in Alzheimer's Disease after Bacillus Calmette Guerin (BCG) vaccination in older adults. 64 samples shares cns, peripheral, alzheimer
- GSE252331 The post-septic peripheral myeloid compartment reveals unexpected diversity in myeloid-derived suppressor cells 34 samples shares peripheral, myeloid
- GSE299831 KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease [RNA-seq] 12 samples shares cns
- GSE139555 Peripheral clonal expansion of T lymphocytes associates with tumour infiltration and response to cancer immunotherapy 32 samples shares infiltration, peripheral
- GSE299850 KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease 36 samples shares cns
- GSE287322 Molecular signatures define BAP1-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes 29 samples shares cns
- GSE281250 Deubiquitinase USP9X regulates Wnt-signaling to control CNS vascular formation and barrier maintenance [Human] 10 samples shares cns
- GSE281106 Single-cell RNA-seq of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases [scRNAseq_KR_SGI] 352 samples shares peripheral
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.