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Histone 3 lysine 56 acetylation (H3K56ac) regulates extrachromosomal DNA (ecDNA) hub biogenesis

GSE296003 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/01/21 Platform GPL18573
Summary
Extrachromosomal DNAs (ecDNAs) play an important role in tumor progression. ecDNA hubs have been shown to be anchored by BRD4, a chromatin reader. However, the epigenetic regulation of ecDNA hub biogenesis remains unknown. Here we show that histone 3 lysine 56 acetylation (H3K56ac) mark binds to BRD4 specifically. Analysis of ChIP-seq datasets showed that both H3K56ac and H3K27ac co-occupied with BRD4 binding at the ecDNA-chromosome interaction sites and ecDNA itself.
Published in
Histone 3 lysine 56 acetylation (H3K56ac) regulates extrachromosomal DNA (ecDNA) hub maintenance
Liao LZ, Wu CJ, Chen YA et al. · Neoplasia (New York, N.Y.) 2026 · PMID 41496274 · doi:10.1016/j.neo.2025.101269
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Also filed as BioProject PRJNA1257306 and SRA study SRP582447. Searching any of these in the dataset finder brings you back here.

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