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Stage-specific degradation of cyclin D3 orchestrates myelopoiesis and restrains MPN development [RNA-seq]

GSE296131 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/01 Platform GPL34328
Summary
Cyclin D3 is critical for myelopoiesis, with its rapid, stage-specific degradation regulating normal granulocyte-monocyte differentiation. Using a knock-in mouse model with a degradation-resistant cyclin D3 variant (D3T283A), we show that sustained cyclin D3 levels enhance granulocyte-monocyte output, cause microcytic erythrocytes, thrombocytosis, and extramedullary hematopoiesis. Splenic HSPCs from D3T283A mice exhibit increased self-renewal and competitive repopulation advantage. Prolonged D3T283A expression drives a high-penetrance myeloproliferative neoplasm, reducing survival.
Published in
Stage-Specific Degradation of Cyclin D3 Orchestrates Myelopoiesis and Restrains Myeloproliferative Neoplasm Development
Mucha B, Tarallo V, Abbas A et al. · Cancer research 2026 · PMID 42223968 · doi:10.1158/0008-5472.CAN-25-4990
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Also filed as BioProject PRJNA1257848 and SRA study SRP582642. Searching any of these in the dataset finder brings you back here.

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