The promyelocytic leukemia PML protein is a key immune suppressor in triple-negative breast cancer
RNA-seq (gene expression) · mouse · 2 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296217_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1258216 and SRA study SRP582803. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE300149 Targeting intrinsically disordered nuclear protein 1 (NUPR1) with single-domain antibodies alleviates triple-negative breast cancer (TNBC) progression in vivo 8 samples shares triple-negative, protein, breast
- GSE292013 Impact of PD-L1 overexpression on immune checkpoint inhibitor efficacy in triple-negative breast cancer using a 4T1 murine model. 12 samples shares triple-negative, breast
- GSE303505 Epithelial-mesenchymal transition is associated with altered immune composition and cytotoxic function in triple-negative breast cancer 12 samples shares triple-negative, breast
- GSE317623 AADAT-Driven Metabolic Control of Malate and CoQ₁₀ Shapes Immune Evasion in Triple-Negative Breast Cancer 9 samples shares triple-negative, breast
- GSE310100 Multi-omics profiling uncovers immune-molecular clusters with distinct chemo-immunotherapeutic vulnerabilities in a mouse model of triple-negative breast cancer 4 samples shares triple-negative, breast
- GSE329623 Integrated single-cell RNA sequencing and untargeted metabolomics reveals β-elemene’s immune and metabolic modulation in triple-negative breast cancer 2 samples shares triple-negative, breast
- GSE295176 FAM114A1 Promotes Immune Evasion of Triple-negative Breast Cancer by Simultaneously Activating PI3K/AKT Signaling and Disrupting E2F4-condensate Formation 2 samples shares triple-negative, breast
- GSE304115 Bulk RNA-seq of Genetically Diverse Triple-Negative Breast Cancer Mouse Models Treated with Immunotherapy, Chemotherapy, Erlotinib, or Trametinib 309 samples shares triple-negative, breast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.