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Sustained MYB activity drives emergent enhancer activation and precise enhancer-promoter interactions

GSE296242 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 81 samples Submitted 2026/05/01 Platform GPL16417Platform GPL18573Platform GPL24676Platform GPL19057
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 81 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
81 samples: 21 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemiaBlood · 2026
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemia
Lau IJ, Bloye G, Smith AL et al. · Blood 2026 · PMID 41949410 · doi:10.1182/blood.2025030424
This dataset
Open GSE296242 in finder → Find more RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296242_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1258259 and SRA study SRP582681. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41949410) ↗
Study design
21 conditions, mostly in triplicate
ATAC-seq in E14 (TOT2N variant) cells contain… ×3 ATAC-seq in E14 (TOT2N variant) cells contain… ×3 ATAC-seq in wild type E14 (TOT2N variant) cel… ×3 Capture-C in E14 (TOT2N variant) cells with r… ×3 Capture-C in E14 (TOT2N variant) cells with T… ×3 Capture-C in E14 (TOT2N variant) cells with T… ×3 Capture-C in E14 (TOT2N variant) cells with T… ×3 Capture-C in E14 (TOT2N variant) cells with T… ×3 +33 more

Supports a case/control comparison: 5 samples read as cases, 8 as controls.

How we read this: 21 replicated groups read from 81 sample titles; they account for 61 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 41 more — browse all 81 samples with per-sample file links →

Datasets on a similar topic

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.