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Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer [ChIP-seq]

GSE296422 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/04/24 Platform GPL24676
Summary
Chromatin architecture plays a key role in development and cancer, yet most studies lack mechanistic depth due to widespread epigenomic remodeling. To address this, we tracked chromatin structure dynamics during the progression of endocrine resistance in ER+ breast cancer using Hi-C, chromatin accessibility, epigenomic, and transcriptomic profiling. We uncovered a critical role for H3K9 methylation and the demethylase KDM4C in driving proliferation of cells fated to become resistant through a non-genomic estrogen-mediated mechanism. These findings highlight the mechanistic contribution of chromatin regulation in therapy resistance and offer a blueprint for studying similar processes in cancer, development, and cell fate decisions.
Published in
Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer
Garcia-Martinez L, Zha M, Borges RL et al. · Genes & development 2026 · PMID 41412800 · doi:10.1101/gad.352982.125
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Also filed as BioProject PRJNA1259255 and SRA study SRP583295. Searching any of these in the dataset finder brings you back here.

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