Transcriptional profiling of Wilms tumor via single nuclei RNA sequencing
Single-nucleus RNA-seq · human · 3 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Topic
- Wilms tumourThis series is part of our curated briefing on it.
- Samples
- 3 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296618_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1260243 and SRA study SRP583797. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 3 more — browse all 3 samples with per-sample file links →
- GSE200256 Single nuclear RNASeq Analysis of Anaplastic and Favourable Histology Hu_Wilms Tumor 40 samples same disease briefing · shares wilms
- GSE273662 Molecular characterization of Wilms' Tumor: insights from single nucleus analystics on Wilms' Tumor development and oncogenesis 14 samples same disease briefing · shares wilms
- GSE270330 Proteasome inhibition sensitizes anaplastic Wilms tumor to actinomycin D 36 samples same disease briefing · shares wilms
- GSE246479 Modeling high-risk blastemal and metastatic Wilms tumors by reprogramming WiT49 cells 6 samples same disease briefing · shares wilms
- GSE298590 The transcriptomic data of the Wilms tumor cell line 6 samples same disease briefing · shares wilms
- GSE303967 DNA methylation and transcriptomic profiles of Wilms tumour reveal new deregulated genes and epigenetic processes relevant for tumour stratification and management 45 samples same disease briefing · shares wilms
- GSE243871 Single-Cell multi-omics reveals disrupted gene regulatory landscape and cell differentiation by Wilms tumor-associated ENL mutation in the developing kidney 28 samples same disease briefing · shares wilms
- GSE25965 Transduction signaling signature of Wilms tumor revealed by parallel analysis of kidney differentiation 78 samples same disease briefing · shares wilms
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.