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HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis

GSE296619 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/16 Platform GPL24676
Summary
Triple-negative breast cancer (TNBC), the most lethal breast cancer subtype, demonstrates poor prognosis due to its high rates of metastasis, recurrence, and mortality. The metastatic potential in TNBC patients serves as a critical determinant of clinical outcomes. The high mobility group AT-hook 2 (HMGA2) has emerged as a novel chromatin architectural regulator, its specific role in TNBC metastasis requires further investigation.To investigate the mechanism of HMGA2 regulation of TNBC metastasis,we performed RNA-sequencing using shNC or shHMGA2 from MDA-MB-231 cells.
Published in
HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis
Qiao L, Liang Z, Ma P et al. · Frontiers in immunology 2025 · PMID 40475780 · doi:10.3389/fimmu.2025.1590368
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Also filed as BioProject PRJNA1260249 and SRA study SRP583800. Searching any of these in the dataset finder brings you back here.

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