GEO series
Effects of hypoxia on brain gene expression in a mouse model of Parkinson’s disease
GSE296779
Mus musculus
Expression profiling by high throughput sequencing
48 samples
2025/07/14
GPL21103
Summary
The purpose of this study was to evaluate whether chronic, continuous hypoxia (breathing 11% FIO2) would improve neurodegenerative disease in a mouse model of Parkinson's disease, which was modeled through intrastriatal injection of a-synuclein preformed fibrils (PFFs). We find that chronic, continuous hypoxia helps to prevent further neurodegeneration and alleviate neurological disease.
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Paper (PMID 40770507) ↗
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