Effect of overexpression of aging-associated transcription factors on epithelial cells.
RNA-seq (gene expression) · human · 64 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 64 samples: 64 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging femalesNAR molecular medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296787_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1261051 and SRA study SRP584230. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 24 samples read as cases, 8 as controls.
How we read this: Read from 64 sample titles: 64 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8976704 Ishikawa cells, empty vector control, rep1 [L001]
- GSM8976705 Ishikawa cells, empty vector control, progesterone-estrodiol-cyclic AMP treated, rep1 [L001]
- GSM8976706 Ishikawa cells, empty vector control, rep2 [L001]
- GSM8976707 Ishikawa cells, empty vector control, progesterone-estrodiol-cyclic AMP treated, rep2 [L001]
- GSM8976708 Ishikawa cells, empty vector control, rep3 [L001]
- GSM8976709 Ishikawa cells, empty vector control, progesterone-estrodiol-cyclic AMP treated, rep3 [L001]
- GSM8976710 Ishikawa cells, empty vector control, rep4 [L001]
- GSM8976711 Ishikawa cells, empty vector control, progesterone-estrodiol-cyclic AMP treated, rep4 [L001]
- GSM8976712 Ishikawa cells, Foxc1 and Six1 transfected, rep1 [L001]
- GSM8976713 Ishikawa cells, Foxc1 and Six1 transfected, progesterone-estrodiol-cyclic AMP treated, rep1 [L001]
- GSM8976714 Ishikawa cells, Foxc1 and Six1 transfected, rep2 [L001]
- GSM8976715 Ishikawa cells, Foxc1 and Six1 transfected, progesterone-estrodiol-cyclic AMP treated, rep2 [L001]
- GSM8976716 Ishikawa cells, Foxc1 and Six1 transfected, rep3 [L001]
- GSM8976717 Ishikawa cells, Foxc1 and Six1 transfected, progesterone-estrodiol-cyclic AMP treated, rep3 [L001]
- GSM8976718 Ishikawa cells, Foxc1 and Six1 transfected, rep4 [L001]
- GSM8976719 Ishikawa cells, Foxc1 and Six1 transfected, progesterone-estrodiol-cyclic AMP treated, rep4 [L001]
- GSM8976720 Ishikawa cells, Foxc1 transfected, rep1 [L001]
- GSM8976721 Ishikawa cells, Foxc1 transfected, progesterone-estrodiol-cyclic AMP treated, rep1 [L001]
- GSM8976722 Ishikawa cells, Foxc1 transfected, rep2 [L001]
- GSM8976723 Ishikawa cells, Foxc1 transfected, progesterone-estrodiol-cyclic AMP treated, rep2 [L001]
- GSM8976724 Ishikawa cells, Foxc1 transfected, rep3 [L001]
- GSM8976725 Ishikawa cells, Foxc1 transfected, progesterone-estrodiol-cyclic AMP treated, rep3 [L001]
- GSM8976726 Ishikawa cells, Foxc1 transfected, rep4 [L001]
- GSM8976727 Ishikawa cells, Foxc1 transfected, progesterone-estrodiol-cyclic AMP treated, rep4 [L001]
- GSM8976728 Ishikawa cells, Six1 transfected, rep1 [L001]
- GSM8976729 Ishikawa cells, Six1 transfected, progesterone-estrodiol-cyclic AMP treated, rep1 [L001]
- GSM8976730 Ishikawa cells, Six1 transfected, rep2 [L001]
- GSM8976731 Ishikawa cells, Six1 transfected, progesterone-estrodiol-cyclic AMP treated, rep2 [L001]
- GSM8976732 Ishikawa cells, Six1 transfected, rep3 [L001]
- GSM8976733 Ishikawa cells, Six1 transfected, progesterone-estrodiol-cyclic AMP treated, rep3 [L001]
- GSM8976734 Ishikawa cells,Six1 transfected, rep4 [L001]
- GSM8976735 Ishikawa cells, Six1 transfected, progesterone-estrodiol-cyclic AMP treated, rep4 [L001]
- GSM8976736 Ishikawa cells, empty vector control, rep1 [L002]
- GSM8976737 Ishikawa cells, empty vector control, progesterone-estrodiol-cyclic AMP treated, rep1 [L002]
- GSM8976738 Ishikawa cells, empty vector control, rep2 [L002]
- GSM8976739 Ishikawa cells, empty vector control, progesterone-estrodiol-cyclic AMP treated, rep2 [L002]
- GSM8976740 Ishikawa cells, empty vector control, rep3 [L002]
- GSM8976741 Ishikawa cells, empty vector control, progesterone-estrodiol-cyclic AMP treated, rep3 [L002]
- GSM8976742 Ishikawa cells, empty vector control, rep4 [L002]
- GSM8976743 Ishikawa cells, empty vector control, progesterone-estrodiol-cyclic AMP treated, rep4 [L002]
+ 24 more — browse all 64 samples with per-sample file links →
- GSE315683 Transcriptional and proteome profiling of human bronchial epithelial cell BEAS-2B exposed to e-cigarette aerosol condensate 9 samples shares transcription, epithelial
- GSE302930 Epigenetic Atlas of Bladder Cancer Reveals Master Transcription Factors and Risk-Associated Regulatory Elements in Luminal and Basal-Squamous Molecular Subtypes 92 samples shares transcription, factors
- GSE301298 Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotency 88 samples shares transcription, factors
- GSE275721 Lineage master regulator and cancer-selective partner transcription factors rewire 3D genome topology for tumor-specific gene control 72 samples shares transcription, factors
- GSE293334 Allelic topological centering by transcription factors drives oncogenic multi-enhancer transcriptional regulation [ChIP-seq] 60 samples shares transcription, factors
- GSE275647 Role of Cancer-Associated Fibroblasts in Prognostic Stratification of Advanced-Stage Gastric Cancer through Interacting with Endothelial and Malignant Epithelial Cells [AGC RNA-seq] 216 samples shares epithelial
- GSE292059 Inflammatory Epithelial and Macrophage Pathways Underlie Residual Asthma Exacerbations in Urban Children Treated with Mepolizumab 965 samples shares epithelial
- GSE314310 Cardiopedia-Ligand: a Ligand Stimulation Atlas for Cardiac Function and Transcriptional Response 468 samples shares transcription
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.