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A LINE-1 retrotransposon promotes SEMA3C expression as a cis-regulatory enhancer to sustain breast cancer stem cell survival

GSE296921 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/01 Platform GPL24247
Summary
Transposable elements (TEs), which are under tight epigenetic control, have been co-opted as cis-regulatory elements to regulate gene expression in development and cancer. Among them, long interspersed element 1 (LINE1) retrotransposons are the most abundant and exhibit high activity in embryonic stem cells.To investigate the precise roles of LINE1 in breast cancer stem cells (BCSCs) , we performed total RNA-seq analysis of non-CSCs and CSCs enriched from EO771 cells.
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Also filed as BioProject PRJNA1261939 and SRA study SRP585011. Searching any of these in the dataset finder brings you back here.

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