PGR Isoform Modulation via Enhancer Activation Regulates Progesterone Signaling in Human Endometrial Stromal Cells [RNA-Seq]
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Progesterone receptor isoform modulation via enhancer activation regulates progesterone signaling in endometrial stromal cellsF&S science · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296931_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1261952 and SRA study SRP584653. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8979979 NT gRNA Veh R1 NT gRNA Veh
- GSM8979980 NT gRNA Veh R2 NT gRNA Veh
- GSM8979981 NT gRNA Veh R3 NT gRNA Veh
- GSM8979982 NT gRNA MPA R1 NT gRNA MPA
- GSM8979983 NT gRNA MPA R2 NT gRNA MPA
- GSM8979984 NT gRNA MPA R3 NT gRNA MPA
- GSM8979985 U1U2 gRNAs Veh R1 U1U2 gRNAs Veh
- GSM8979986 U1U2 gRNAs Veh R2 U1U2 gRNAs Veh
- GSM8979987 U1U2 gRNAs Veh R3 U1U2 gRNAs Veh
- GSM8979988 U1U2 gRNAs MPA R1 U1U2 gRNAs MPA
- GSM8979989 U1U2 gRNAs MPA R2 U1U2 gRNAs MPA
- GSM8979990 U1U2 gRNAs MPA R3 U1U2 gRNAs MPA
- GSM8979991 Promoter gRNA Veh R1 Promoter gRNA Veh
- GSM8979992 Promoter gRNA Veh R2 Promoter gRNA Veh
- GSM8979993 Promoter gRNA Veh R3 Promoter gRNA Veh
- GSM8979994 Promoter gRNA MPA R1 Promoter gRNA MPA
- GSM8979995 Promoter gRNA MPA R2 Promoter gRNA MPA
- GSM8979996 Promoter gRNA MPA R3 Promoter gRNA MPA
- GSE246591 Transcriptomic exploration of decidualizing human endometrial stromal cell dynamics 40 samples shares endometrial, stromal
- GSE234338 Extracellular vesicles (EVs) secreted by human aneuploid embryos contain a distinct RNA cargo and upregulate MUC1 transcription in decidualised endometrial stromal cells (dESCs) 32 samples shares endometrial, stromal
- GSE325553 Comparative transcriptomic profiling of human 3D endometrial stromal organoids under distinct decidualization stimuli 20 samples shares endometrial, stromal
- GSE295509 Deciphering ESR1-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape [ESR1_RNAseq] 12 samples shares endometrial, stromal
- GSE298658 Transcriptomic profiling of endometrial and dermal mesenchymal stromal cells before and after treatment with menstrual fluid 12 samples shares endometrial, stromal
- GSE294481 Effects of Amino Acid Restriction on Decidualization of Human Endometrial Stromal Cells 12 samples shares endometrial, stromal
- GSE240926 Adiposity alters protective mechanisms of progesterone through dysregulation of endometrial metallothionein expression 12 samples shares progesterone, endometrial
- GSE297767 Targeted p63 isoform modulation corrects dominant mutations in AEC syndrome without disrupting epidermal homeostasis [human RNA-seq] 12 samples shares modulation, isoform
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.