Neuroblastoma tumors are sensitive to ferroptosis inducers – GPX4 inhibitors
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumorsGenome medicine · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296939_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1261963 and SRA study SRP584687. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8980088 SK_N_AS_01_Control
- GSM8980089 SK_N_AS_02_Control
- GSM8980090 SK_N_AS_03_Control
- GSM8980091 SK_N_AS_01_ML210
- GSM8980092 SK_N_AS_02_ML210
- GSM8980093 SK_N_AS_03_ML210
- GSM8980094 SK_N_BE_01_Control
- GSM8980095 SK_N_BE_02_Control
- GSM8980096 SK_N_BE_03_Control
- GSM8980097 SK_N_BE_01_ML210
- GSM8980098 SK_N_BE_02_ML210
- GSM8980099 SK_N_BE_03_ML210
- GSE313741 A covalent fragment screen identifies ferroptosis induced by GPX4 inhibition as a vulnerability of senescent cells [PC3] 25 samples shares gpx4, ferroptosis
- GSE307575 A covalent fragment screen identifies ferroptosis induced by GPX4 inhibition as a vulnerability of senescent cells 11 samples shares gpx4, ferroptosis
- GSE330931 Radiopharmaceuticals enhance CAR T-cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling 32 samples shares neuroblastoma, sensitive
- GSE330929 Radiopharmaceuticals enhance CAR T-cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling [RNA-Seq] 24 samples shares neuroblastoma, sensitive
- GSE317656 Erastin-Induced Ferroptosis Enhances Natural Killer Cell Anti-Tumor Activity and Offers Therapeutic Potential in Neuroblastoma 12 samples shares neuroblastoma, ferroptosis
- GSE319664 RNA-seq analysis of tumors derived from a xenograft model treated with the KDM5B inhibitors JB-157 or JB-161. 29 samples shares inhibitors
- GSE218450 Gene expression profile at single cell level of neuroblastoma tumors 16 samples shares neuroblastoma
- GSE49711 RNA-Seq reveals an unprecedented complexity of the neuroblastoma transcriptome and is suitable for clinical endpoint prediction [RNA-Seq] 498 samples shares neuroblastoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.