GEO series
Radiation triggers a clinically relevant profibrotic p53-mediated DNA damage response in an ex vivo human skin model
GSE297035
Homo sapiens
Expression profiling by high throughput sequencing
55 samples
2026/03/09
GPL34284
Summary
Radiation therapy is a cornerstone of cancer treatment which frequently leads to cutaneous side effects. In a significant proportion of patients, this can progress to debilitating radiation-induced skin fibrosis (RISF). To investigate the early molecular events underlying RISF, we employed a novel human ex vivo model utilizing discarded human skin from elective surgical procedures. This dataset is comprised of irradiated and control skin from 6 human donors post-panniculectomy.
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