GEO series
Multi-omics analysis in EGFR-mutant lung adenocarcinoma
GSE297057
Homo sapiens
Expression profiling by high throughput sequencing
26 samples
2026/05/11
GPL34284
Summary
Using genomic and transcriptomic anaysis, we have identified TP53-GOF mutations as key genomic alterations associated with early resistance to first-line osimertinib therapy in EGFR-mutant NSCLC. Through comprehensive genomic and transcriptomic profiling, we found that TP53-GOF mutations define a biologically distinct subgroup marked by significantly shorter progression-free survival against osimrtinib treatment.
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