GEO series
Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function Through Electrophilic Bromine Transfer
GSE297104
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2026/05/26
GPL24247
Summary
We have discovered a new α,α-gem-dibromo lactam that activates transcription factor Nrf2 and demonstrates anti-inflammatory activities. After the compounds were screened in ARE luciferase reporter assay, RNA-seq and Ingenuity Pathway Analysis was used to capture the detailed pharmacological profiles.
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