RNA-seq profiling of radioiodine-treated differentiated thyroid cancer cells reveals DDR pathway regulation during iodine tolerance
Single-cell RNA-seq · human · 8 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Topic
- Thyroid cancerThis series is part of our curated briefing on it.
- Samples
- 8 samples: 4 × K1 cell, Control vs 4 × K1 cell, irradiatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhibition of ATM reverses radioiodine resistance in differentiated thyroid cancer via genotoxic stress amplificationJournal of translational medicine · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297164_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1262923 and SRA study SRP585323. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 2 replicated groups read from 8 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8984869 K1 cell, Control1 K1 cell, Control
- GSM8984870 K1 cell, Control2 K1 cell, Control
- GSM8984871 K1 cell, Control3 K1 cell, Control
- GSM8984872 K1 cell, Control4 K1 cell, Control
- GSM8984873 K1 cell, irradiated1 K1 cell, irradiated
- GSM8984874 K1 cell, irradiated2 K1 cell, irradiated
- GSM8984875 K1 cell, irradiated3 K1 cell, irradiated
- GSM8984876 K1 cell, irradiated4 K1 cell, irradiated
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- GSE191288 Dissecting the transcriptomic landscape of the human papillary thyroid carcinoma by single cell RNA-sequencing 7 samples same disease briefing · shares rna-seq, thyroid
- GSE217851 RNA-seq analysis in thyroid cancer cells knocking down METTL3 4 samples same disease briefing · shares rna-seq, thyroid
- GSE224357 H3K27ac ChIP-seq and RNA-seq of papillary thyroid carcinoma patient's tissues and paired normal tissues 12 samples same disease briefing · shares rna-seq, thyroid
- GSE265794 TGFBR3 inhibits the aggressive of papillary thyroid cancer by inhibiting PI3K/AKT pathway and EMT 6 samples same disease briefing · shares thyroid
- GSE299493 Erianin induces apoptosis and pyroptosis via MAPK/ERK and PI3K/Akt pathways and synergizes with anlotinib in anaplastic thyroid carcinoma 6 samples same disease briefing · shares thyroid
- GSE310793 PRECISE: A prognostic thyroid follicular-cell derived gene signature for papillary thyroid carcinoma 109 samples same disease briefing · shares thyroid
- GSE165724 Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma 74 samples same disease briefing · shares thyroid
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.