The DLX2-LAP2α axis licenses ectomesenchymal specification by unlocking chromatin barriers for craniofacial regeneration [RNA-seq]
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 9 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- DLX2 acts as a pioneer factor and drives Msx1(+) ectomesenchyme formation from embryonic stem cellsScience advances · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297346_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1259432 and SRA study SRP585134. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 9 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8989010 D8_Msx1-_rep1 D8_Msx1
- GSM8989011 D8_Msx1-_rep2 D8_Msx1
- GSM8989012 D8_Msx1+_rep1 D8_Msx1+
- GSM8989013 D8_Msx1+_rep2 D8_Msx1+
- GSM8989014 D16_Msx1-_rep1 D16_Msx1
- GSM8989015 D16_Msx1-_rep2 D16_Msx1
- GSM8989016 D16_Msx1+_rep1 D16_Msx1+
- GSM8989017 D16_Msx1+_rep2 D16_Msx1+
- GSM8989018 ES_rep1 ES
- GSM8989019 ES_rep2 ES
- GSM8989020 Dlx2+dox_rep1 Dlx2+dox
- GSM8989021 Dlx2+dox_rep2 Dlx2+dox
- GSM8989022 Dlx2-dox_rep1 Dlx2-dox
- GSM8989023 Dlx2-dox_rep2 Dlx2-dox
- GSM8989024 GFP+dox_rep1 GFP+dox
- GSM8989025 GFP+dox_rep2 GFP+dox
- GSM8989026 GFP-dox_rep1 GFP-dox
- GSM8989027 GFP-dox_rep2 GFP-dox
- GSE297347 The DLX2-LAP2α axis licenses ectomesenchymal specification by unlocking chromatin barriers for craniofacial regeneration [scRNA-seq] 4 samples shares dlx2-lap2, ectomesenchymal, specification, craniofacial, regeneration, unlocking, chromatin, licenses
- GSE297345 The DLX2-LAP2α axis licenses ectomesenchymal specification by unlocking chromatin barriers for craniofacial regeneration [CUT&Tag] 16 samples shares dlx2-lap2, ectomesenchymal, specification, craniofacial, regeneration, unlocking, chromatin, licenses
- GSE295406 Polycomb Chromatin Topology Enables Long-Range Enhancer Recruitment during Craniofacial Development [RNA-seq] 24 samples shares craniofacial, chromatin
- GSE250177 Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification [RNA-seq] 12 samples shares specification, chromatin
- GSE296815 Polycomb Chromatin Topology Enables Long-Range Enhancer Recruitment during Craniofacial Development 98 samples shares craniofacial, chromatin
- GSE250178 Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification 54 samples shares specification, chromatin
- GSE295340 Polycomb Chromatin Topology Enables Long-Range Enhancer Recruitment during Craniofacial Development [ChIP-seq] 42 samples shares craniofacial, chromatin
- GSE250176 Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification [CUT&RUN] 42 samples shares specification, chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.