DOT1L enhances BLM-induced pulmonary fibrosis by inducing endothelial-to-mesenchymal transition via H3K79me2 [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 3 × ChIP-H3K79me2-TGFβ vs 2 × ChIP-H3K79me2-ctrlGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- DOT1L Drives Endothelial-to-Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 MethylationAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297647_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1265614 and SRA study SRP586769. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 5 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 5 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8996153 ChIP-H3K79me2-ctrl-rep1 ChIP-H3K79me2-ctrl
- GSM8996154 ChIP-H3K79me2-ctrl-rep2 ChIP-H3K79me2-ctrl
- GSM8996155 ChIP-H3K79me2-ctrl-rep1-input
- GSM8996156 ChIP-H3K79me2-ctrl-rep2-input
- GSM8996157 ChIP-H3K79me2-TGFβ-rep1 ChIP-H3K79me2-TGFβ
- GSM8996158 ChIP-H3K79me2-TGFβ-rep2 ChIP-H3K79me2-TGFβ
- GSM8996159 ChIP-H3K79me2-TGFβ-rep3 ChIP-H3K79me2-TGFβ
- GSM8996160 ChIP-H3K79me2-TGFβ-rep1-input
- GSM8996161 ChIP-H3K79me2-TGFβ-rep2-input
- GSM8996162 ChIP-H3K79me2-TGFβ-rep3-input
- GSE299484 DOT1L enhances BLM-induced pulmonary fibrosis by inducing endothelial-to-mesenchymal transition via H3K79me2 [ChIP-seq] 4 samples shares h3k79me2, dot1l, endothelial-to-mesenchymal, blm-induced, transition, pulmonary, enhances, fibrosis
- GSE297646 DOT1L enhances BLM-induced pulmonary fibrosis by inducing endothelial-to-mesenchymal transition via H3K79me2 [RNA-seq] 6 samples shares h3k79me2, dot1l, endothelial-to-mesenchymal, blm-induced, transition, pulmonary, enhances, fibrosis
- GSE320036 H3K79me2 Profiling Reveals DOT1L Regulated Splicing in MLL-rearranged AML [ChIP-Seq] 56 samples shares h3k79me2, dot1l
- GSE303754 Genome-wide identification of DOT1L-regulated targets via H3K79me2 modification in SW1990 pancreatic cancer cells 2 samples shares h3k79me2, dot1l
- GSE310554 Paired Vascular-Parenchymal Single Nuclei Sequencing Reveals Perturbed Endothelial-to-Mesenchymal Transition in Alzheimer’s Disease 39 samples shares endothelial-to-mesenchymal, transition
- GSE305562 Endothelial RNF20 Suppresses Endothelial-to-Mesenchymal Transition and Safeguards Physiological Angiocrine Signaling to Prevent Congenital Heart Disease [Bulk_polyA RNA-seq] 25 samples shares endothelial-to-mesenchymal, transition
- GSE293411 TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques [AEBP1 RNA-Seq] 12 samples shares endothelial-to-mesenchymal, transition
- GSE237895 Single-cell analysis reveals a novel regulatory mechanism of endothelial-to-mesenchymal transition 12 samples shares endothelial-to-mesenchymal, transition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.