GEO series
scRNA-seq of Lecanamab- and IgG1-treated xenotrasplanted human microglia
GSE297665
Homo sapiens
Expression profiling by high throughput sequencing
10 samples
2025/07/31
GPL20301
Summary
We investigated the transcriptomic changes of human microglia xenotransplanted in a mouse model of AD upon treatment with Lecanamab (Lec) compared to control (IgG1). Single-cell RNA sequencing reveals that Lec treatment induces a transcriptional program in microglia that promotes amyloid plaque removal, involving pathways related to phagocytosis, metabolism, antigen presentation, unfolded protein response, and interferon response.
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Paper (PMID 41286448) ↗
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