GEO series
Synergistic activity of simvastatin and irinotecan chemotherapy against glioblastoma converges on TGF-β
GSE297728
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2026/05/20
GPL30173
Summary
Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with a dismal prognosis and inevitable recurrence after standard-of-care therapy. This warrants the need for rapidly translatable, more effective GBM treatments. We have therefore investigated the therapeutic potential of a novel combination of the repurposed drug simvastatin with irinotecan chemotherapy (CPT-11).
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