TBK1 enhances antifungal immunity by forming a SRC-TBK1 positive feedback loop in phagosomes of macrophages
RNA-seq (gene expression) · mouse · 22 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297902_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1266699 and SRA study SRP587155. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 8 replicated groups read from 22 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9001669 KO_CTRL_2 KO_CTRL
- GSM9001670 KO_CTRL_3 KO_CTRL
- GSM9001671 KO_HKCA-H_1 KO_HKCA-H
- GSM9001672 KO_HKCA-H_2 KO_HKCA-H
- GSM9001673 KO_HKCA-H_3 KO_HKCA-H
- GSM9001674 KO_HKCA-Y_1 KO_HKCA-Y
- GSM9001675 KO_HKCA-Y_2 KO_HKCA-Y
- GSM9001676 KO_HKCA-Y_3 KO_HKCA-Y
- GSM9001677 KO_Zymd_1 KO_Zymd
- GSM9001678 KO_Zymd_2 KO_Zymd
- GSM9001679 KO_Zymd_3 KO_Zymd
- GSM9001680 WT_CTRL_2 WT_CTRL
- GSM9001681 WT_CTRL_3 WT_CTRL
- GSM9001682 WT_HKCA-H_1 WT_HKCA-H
- GSM9001683 WT_HKCA-H_2 WT_HKCA-H
- GSM9001684 WT_HKCA-H_3 WT_HKCA-H
- GSM9001685 WT_HKCA-Y_1 WT_HKCA-Y
- GSM9001686 WT_HKCA-Y_2 WT_HKCA-Y
- GSM9001687 WT_HKCA-Y_3 WT_HKCA-Y
- GSM9001688 WT_Zymd_1 WT_Zymd
- GSM9001689 WT_Zymd_2 WT_Zymd
- GSM9001690 WT_Zymd_3 WT_Zymd
- GSE324935 IFN-γ and TLR9 signaling reprogram tumor-associated macrophages to promote antitumor immunity in melanoma 20 samples shares macrophages, immunity
- GSE295483 Type-I interferon priming signal balances anti-bacterial and anti-tumor trained immunity in alveolar macrophages [RNA-seq] 19 samples shares macrophages, immunity
- GSE286348 Macrophages foster anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction 18 samples shares macrophages, immunity
- GSE261139 Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential 16 samples shares macrophages, enhances
- GSE281001 The C3-C3aR axis modulates trained immunity in alveolar macrophages 8 samples shares macrophages, immunity
- GSE272424 Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages 6 samples shares macrophages, immunity
- GSE254229 ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice 141 samples shares tbk1
- GSE254217 ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits. [in vitro_Microglia] 59 samples shares tbk1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.