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Effect of overepression of HK1 in hepatocellular carcinoma cells

GSE297965 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/18 Platform GPL29480
Summary
Hexokinase (HK), accountable for the phosphorylation of glucose, catalyzes the initial step of glucose metabolism. The HK family encompasses four members (HK1-4) in mammals, and HK1 exhibits the highest affinity for glucose. We found that overexpression of HK1 in Huh7 cells not only promoted the glycolysis pathway but also increased the pathway of asparagine N-linked glycosylation.
Published in
A Unique Intercellular Feedforward Loop From HK1 to TGF-β1 Promotes the Progression of Hepatocellular Carcinoma
Chen QT, Huang QL, Feng DY et al. · Journal of extracellular vesicles 2026 · PMID 41806338 · doi:10.1002/jev2.70255
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Also filed as BioProject PRJNA1267036 and SRA study SRP587410. Searching any of these in the dataset finder brings you back here.

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