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Transcriptomic profiling of tumor-infiltrating Treg cells in Foxp3-Cre-YFP melanoma-bearing mice

GSE298145 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/01/28 Platform GPL24247
Summary
Tregs restrain anti-tumor immunity and facilitate the evasion of tumor cells from immune surveillance, thus has long been considered as a promising target for anti-tumor therapy. Recent studies found that excessive type 1 immune responses (mainly mediated by IFN-γ and IL-12 et al.) in the tumor microenvironment drive Treg fragility that downregulates FOXP3 but upregulates IFN-γ, hereby compromises its suppressive function.The expression level of FOXP3 in Treg cells regulates its immunosuppressive function. Therefore, we sorted FOXP3-high and FOXP3-low Treg cells and strived to find their differentially expressed genes and their functional regulatory mechanisms.
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Direct links to NCBI, no account and no request form: the whole study as GSE298145_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1268420 and SRA study SRP588106. Searching any of these in the dataset finder brings you back here.

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