Fucoidans are senotherapeutics that enhance SIRT6-Dependent DNA repair
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 3 × Senescent WT MEF Eo, Untreated, Mouse vs 3 × Senescent WT MEF Eto, Fucoidan-FV (100 µg/mL), Mouse vs 3 × Senescent WT MEF Eto, Fucoidan-FV (300 µg/mL), Mouse vs 2 × WT MEF, Untreated, MouseGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repairResearch square · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298234_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1268546 and SRA study SRP587962. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 13 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9010218 WT MEF, Untreated, Mouse 6 WT MEF, Untreated, Mouse
- GSM9010219 WT MEF, Untreated, Mouse 4 WT MEF, Untreated, Mouse
- GSM9010220 WT MEF, Untreated, Mouse 5(1)
- GSM9010221 WT MEF, Untreated, Mouse 5(2)
- GSM9010222 Senescent WT MEF Eo, Untreated, Mouse 6 Senescent WT MEF Eo, Un…
- GSM9010223 Senescent WT MEF Eo, Untreated, Mouse 4 Senescent WT MEF Eo, Un…
- GSM9010224 Senescent WT MEF Eo, Untreated, Mouse 5 Senescent WT MEF Eo, Un…
- GSM9010225 Senescent WT MEF Eto, Fucoidan-FV (100 µg/mL), Mouse 6 Senescent WT MEF Eto, F…
- GSM9010226 Senescent WT MEF Eto, Fucoidan-FV (100 µg/mL), Mouse 4 Senescent WT MEF Eto, F…
- GSM9010227 Senescent WT MEF Eto, Fucoidan-FV (100 µg/mL), Mouse 5 Senescent WT MEF Eto, F…
- GSM9010228 Senescent WT MEF Eto, Fucoidan-FV (300 µg/mL), Mouse 6 Senescent WT MEF Eto, F…
- GSM9010229 Senescent WT MEF Eto, Fucoidan-FV (300 µg/mL), Mouse 4 Senescent WT MEF Eto, F…
- GSM9010230 Senescent WT MEF Eto, Fucoidan-FV (300 µg/mL), Mouse 5 Senescent WT MEF Eto, F…
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- GSE319608 Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy 98 samples shares enhance
- GSE243869 KMT2C deficiency enhances HSC mobilization and granulocyte bias in response to G-CSF 78 samples shares enhance
- GSE339044 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [RNA-Seq] 71 samples shares enhance
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- GSE267936 Functional Optic Tract Rewiring via Subtype- and Target-specific Axonal Regeneration and Presynaptic Activity Enhancement (bulk RNA-Seq) 40 samples shares enhance
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.