GEO series
FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective
GSE298566
Mus musculus
Expression profiling by high throughput sequencing
15 samples
2025/06/06
GPL24247
Summary
We performed single-cell RNA sequencing to analyze murine lung tissues exposed to either conventional dose rate (CONV) or FLASH radiation therapy (FLASH-RT). This approach elucidated distinct early immune responses in radiation-induced lung injury and revealed protective mechanisms specific to FLASH irradiation. Systematic characterization of over 135,000 cells within the pulmonary microenvironment uncovered critical immune and stromal cell dynamics that differentiate CONV and FLASH-RT responses. These findings provide mechanistic insights into FLASH-RT's biological effects and its potential clinical applications in thoracic oncology.
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Paper (PMID 40536317) ↗
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