The TBLR1/TBL1 co-factor complex acts as a transcriptional checkpoint in the brown adipose tissue response to prolonged cold exposure
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 12 × BATdKO WT vs 12 × BATdKO KOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The TBLR1/TBL1 Co-Factor Complex Acts as a Transcriptional Checkpoint in the Brown Adipose Tissue Response to Prolonged Cold ExposureFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298802_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1271324 and SRA study SRP589509. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 2 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9023939 BATdKO WT_20293 BATdKO WT
- GSM9023940 BATdKO WT_20315 BATdKO WT
- GSM9023941 BATdKO WT_20320 BATdKO WT
- GSM9023942 BATdKO WT_20329 BATdKO WT
- GSM9023943 BATdKO WT_20339 BATdKO WT
- GSM9023944 BATdKO WT_20346 BATdKO WT
- GSM9023945 BATdKO KO_20303 BATdKO KO
- GSM9023946 BATdKO KO_20309 BATdKO KO
- GSM9023947 BATdKO KO_20311 BATdKO KO
- GSM9023948 BATdKO KO_20312 BATdKO KO
- GSM9023949 BATdKO KO_20319 BATdKO KO
- GSM9023950 BATdKO KO_20345 BATdKO KO
- GSM9023951 BATdKO WT_20291 BATdKO WT
- GSM9023952 BATdKO WT_20330 BATdKO WT
- GSM9023953 BATdKO WT_20340 BATdKO WT
- GSM9023954 BATdKO WT_20351 BATdKO WT
- GSM9023955 BATdKO WT_20353 BATdKO WT
- GSM9023956 BATdKO WT_20354 BATdKO WT
- GSM9023957 BATdKO KO_20301 BATdKO KO
- GSM9023958 BATdKO KO_20310 BATdKO KO
- GSM9023959 BATdKO KO_20321 BATdKO KO
- GSM9023960 BATdKO KO_20343 BATdKO KO
- GSM9023961 BATdKO KO_20344 BATdKO KO
- GSM9023962 BATdKO KO_20348 BATdKO KO
- GSE254919 Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy [ATAC-seq] 12 samples shares checkpoint, adipose
- GSE293613 Transcriptome analysis in the prefrontal cortex of Tbl1xr1 KI heterozygous mice treated with drug 58 samples shares tbl1
- GSE299686 Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma [bulk RNA-seq] 178 samples shares checkpoint
- GSE293819 Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance 142 samples shares checkpoint
- GSE299683 Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma [scRNA-seq] 125 samples shares checkpoint
- GSE313732 Type I IFN Dynamics Orchestrate Protective ICAM1⁺ Neutrophil Heterogeneity as an Early Checkpoint for Survival in Lethal Viral Infection [RNA-Seq] 78 samples shares checkpoint
- GSE278990 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity 73 samples shares checkpoint
- GSE223424 Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease 57 samples shares checkpoint
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.