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Loss of Histone Methyltransferase Ezh2 Exacerbates Polarization of Macrophages toward M2-Like Phenotypes by Hepatocellular Carcinoma [ATAC-seq]

GSE298839 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/02/22 Platform GPL34328
Summary
The roles of epigenetic regulator Ezh2 in TAMs of liver cancer still unclear. In this study, our results demonstrated that the absence of Ezh2 in bone marrow-derived macrophages (BMDMs) exacerbated M2-like phenotypic changes upon incubation with conditioned media (CM) from hepatocellular carcinoma (HCC) cell line Hepa1-6. The ATAC-seq revealed that the promoter regions of pyruvate metabolic process-related genes were more accessible in treated BMDMs Ezh2 KO.
Published in
Loss of Ezh2 promotes M2-like macrophage polarization in hepatocellular carcinoma
Weerasopon K, Boonmee A, Kueanjinda P et al. · iScience 2026 · PMID 41869562 · doi:10.1016/j.isci.2026.115180
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Also filed as BioProject PRJNA1271471 and SRA study SRP589566. Searching any of these in the dataset finder brings you back here.

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