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RNA-seq of B-cell lymphoma treated with Ibrutinib and CAR T cells

GSE299395 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/06/10 Platform GPL24676
Summary
This dataset presents RNA sequencing (RNA-seq) data from human B-cell lymphoma HT tumors established in immunodeficient mice. Tumors were treated with ibrutinib (IB), CD19-directed chimeric antigen receptor T cells (CAR T cells), or a combination of both. The study aimed to investigate transcriptomic changes and treatment-related gene expression differences induced by monotherapy or combination therapy. These data provide insight into the molecular responses to IB and CAR T-cell treatment in vivo and may help elucidate mechanisms underlying therapeutic synergy.
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Direct links to NCBI, no account and no request form: the whole study as GSE299395_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1274356 and SRA study SRP591178. Searching any of these in the dataset finder brings you back here.

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