GEO series
Endothelial miR-33 protects from atherosclerotic lesion initiation and acute inflammation
GSE299560
Homo sapiens
Expression profiling by high throughput sequencing
11 samples
2026/06/10
GPL24676
Summary
Human aortic endothelial cells (HAEC) were treated with TNF, or TNF and LDL, in order to determine how cholesterol loading influences HAEC inflammatory responses to TNF. Cells were also transfected with a miR-33 mimic to determine which of the LDL-mediated perturbations are dependent on cholesterol-induced miR-33 dysregulation. From these analyses, we determined that miR-33 is able to rescue a signifcant portion of the genes dysregulated in hypercholesteremic inflammation compared to normocholesteremic inflammation.
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