Pan-cyclin-dependent kinase inhibition is a potential treatment for adenoid cystic carcinoma that downregulates the MYB::NFIB fusion and induces tumor regression
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × ACCX11, control, 24 h, biol vs 3 × ACCX11, dinaciclib, 24 h, biol vs 3 × ACC67, control, 24 h, biol vs 3 × ACC67, dinaciclib, 24 h, biolGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Pan-cyclin-dependent kinase inhibition is a potential treatment for adenoid cystic carcinoma that downregulates the MYB::NFIB fusion and induces tumor regressionCancer communications (London, England) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE299929_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1277341 and SRA study SRP592346. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9050246 ACCX11, control, 24 h, biol repl 1 ACCX11, control, 24 h, …
- GSM9050247 ACCX11, control, 24 h, biol repl 2 ACCX11, control, 24 h, …
- GSM9050248 ACCX11, control, 24 h, biol repl 3 ACCX11, control, 24 h, …
- GSM9050249 ACCX11, dinaciclib, 24 h, biol repl 1 ACCX11, dinaciclib, 24 …
- GSM9050250 ACCX11, dinaciclib, 24 h, biol repl 2 ACCX11, dinaciclib, 24 …
- GSM9050251 ACCX11, dinaciclib, 24 h, biol repl 3 ACCX11, dinaciclib, 24 …
- GSM9050252 ACC67, control, 24 h, biol repl 1 ACC67, control, 24 h, b…
- GSM9050253 ACC67, control, 24 h, biol repl 2 ACC67, control, 24 h, b…
- GSM9050254 ACC67, control, 24 h, biol repl 3 ACC67, control, 24 h, b…
- GSM9050255 ACC67, dinaciclib, 24 h, biol repl 1 ACC67, dinaciclib, 24 h…
- GSM9050256 ACC67, dinaciclib, 24 h, biol repl 2 ACC67, dinaciclib, 24 h…
- GSM9050257 ACC67, dinaciclib, 24 h, biol repl 3 ACC67, dinaciclib, 24 h…
- GSE267370 RNA-seq analysis after dTAG-mediated MYB depletion in Jurkat cells 36 samples shares myb
- GSE227973 MY-COMP, an inhibitor of the transcriptional activity of YAP-B-MYB, identifies NEK2 as a novel mediator of YAP oncogenesis in uveal melanoma cells [RNA-seq] 21 samples shares myb
- GSE263511 Bidirectional enhancer RNAs regulate different MYB promoters 21 samples shares myb
- GSE240799 A-MYB substitutes for B-MYB in activating cell cycle genes and in stimulating proliferation 16 samples shares myb
- GSE293321 Transcriptomic profiling of human trophoblast stem cells (hTSCs) and HTR-8/SVneo cells under normal and MYBL2 knockdown conditions 12 samples shares myb
- GSE305485 Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia 12 samples shares myb
- GSE292666 MYB and HIF1α crosstalk drives hypoxia-induced transcriptional reprogramming and adaptive signaling alterations in pancreatic cancer [RNA-seq] 12 samples shares myb
- GSE279126 Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction in sepsis-associated lung injury via inhibiting ACLY/MYB/RIG-I axis 9 samples shares myb
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.